Concomitant utilization of dihydrocodeine and sedative medicines for example benzodiazepines or associated drugs might end in sedation, respiratory depression, coma and Loss of life. Due to these risks, concomitant prescribing with these sedative medicines needs to be reserved for patients for whom alternative treatment possibilities are not possible. If a decision is made to prescribe dihydrocodeine concomitantly with sedative medicines, the lowest powerful dose really should be applied, as well as the length of treatment really should be as quick as you can (see also common dose recommendation in section 4.

Patients may also dietary supplement their treatment with supplemental pain relievers. These could be signs which the patient is producing tolerance. The risks of producing tolerance should be discussed towards the patient.

Browse the Medication Guidebook supplied by your pharmacist Before you begin having acetaminophen/caffeine/dihydrocodeine and every time you have a refill. For those who have any concerns, request your health care provider or pharmacist.

Controlled release dihydrocodeine is available for equally pain and coughing, as indicated down below, as waxy tablets containing sixty to a hundred and twenty mg of the drug. Some formulations, intended to be used versus coughing and also the like, have other active ingredients including antihistamines, decongestants and others.

The potential risk of establishing serotonin syndrome may differ in between different opioid and serotonergic medicine mixtures

Sedative medicines for get more info instance benzodiazepines or connected drugs: The concomitant usage of opioids with sedative medicines for example benzodiazepines or related drugs enhances the threat of sedation, respiratory depression, coma and Dying as a result of additive CNS depressant outcome. The dose and duration of concomitant use really should be limited (see section 4.4).

5.3 Preclinical safety info There aren't any pre-clinical information of relevance towards the prescriber which are further to that presently included in other sections from the SPC.

Drug withdrawal syndrome may come about upon abrupt cessation of therapy or dose reduction. When a patient no longer necessitates therapy, it can be sensible to taper the dose gradually to minimise symptoms of withdrawal. Tapering from the high dose could take months to months.

This is simply not an entire list of side effects and others may take place. Simply call your doctor for medical suggestions about side effects.

This allows your medical professional to discover Should the medicine is working thoroughly and to make your mind up if it is best to keep on to implement it. Blood and urine tests might be required to check for unwanted effects.

Gastric contents might therefore should be emptied, as this can be valuable in eliminating unabsorbed drug, specially when a prolonged release formulation has been taken.

This product may perhaps contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist For additional information.

AA. Characterization of your human cytochrome P450 enzymes associated with the metabolism of dihydrocodeine.

A healthcare Specialist should be consulted just before getting any drug, changing any diet program or commencing or discontinuing any study course of treatment.